Panax ginseng Root Extract

Panax ginseng Root Extract
Panax ginseng Root Extract
Is included in:
Qualia Energy Shot
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The roots of Panax ginseng (Korean ginseng, Asian ginseng) have been used for thousands of years in China, Korea, and Japan. In these traditions, it was used as a Qi tonic to promote strength, restore vitality, support energy, and to quiet the spirit. “Panax” means “all-healing” in Greek. It is aptly named, based on both its traditional uses and modern scientific research [1]. P. ginseng is characterized as an adaptogen—it is used for invigorating and fortifying in times of higher stress or greater demands. P. ginseng is also used to support the capacity for mental and physical work. A great deal of research on P. ginseng has been related to the immune system, where it acts as an immune adaptogen, supporting both the innate and adaptive immune systems [2]. The main bioactive compounds of Panax ginseng are ginsenosides [3].*


TOP BENEFITS OF PANAX GINSENG ROOT EXTRACT

Supports cognitive function*

Supports general immune health*

Supports upper respiratory health*


QUALIA’S PANAX GINSENG  ROOT EXTRACT SOURCING

Panax ginseng Root Extract is made from dried roots. 

Panax ginseng Root Extract is standardized to contain not less than 4% ginsenosides.

Panax ginseng Root Extract is non-GMO, Halal, Kosher, gluten-free and vegan.


PANAX GINSENG  ROOT EXTRACT DOSING PRINCIPLES AND RATIONALE

Because Panax ginseng is an adaptogen, we consider dosing to follow hormetic principles (see Qualia Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone. The established daily dose range for Panax ginseng root extracts standardized for 4% ginsenosides is 40-200 mg. Our dosage is consistent with this established dosage range.*


PANAX GINSENG KEY MECHANISMS

Supports brain function*

Supports cognitive performance* [4–12]

Supports resistance to mental fatigue* [4,5]

Supports brain metabolism* [13]

Supports neuroprotective functions* [14–17]


Supports healthy immune function* 

Supports general immune health* [18–22]

Supports innate immunity* [18,23–30]

Supports adaptive immunity* [18,19,23–26,29–31]

Supports cellular intrinsic immune defenses* [32–39] 

Supports mucosal immunity* [40,41]

Supports immune tolerance* [42–48] 

Supports immune cell function* [18,19,23–31,49] 

Supports immune signaling* [19,23,25,41,50–53]

Supports immune organ function* [51]


Promotes healthy aging and general well-being*

Supports a healthy gut microbiota* [41,54,55]

Supports healthy blood glucose levels* [4,5,56]

Supports antioxidant defenses* [15,51,57–61]

Supports Nrf2 signaling and phase II detox enzymes* [12,23,62–66]

Supports autophagy* [14,67–77]

Supports AMPK signaling* [68,78]

Supports mitochondrial function* [61,74,79–86]

Modulates advanced glycation end product (AGE) production* [57,59,60,87–91]


*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.


REFERENCES

[1]A.R. Bilia, M.C. Bergonzi, J. Ginseng Res. 44 (2020) 179–193.

[2]S.-W. Kang, H.-Y. Min, Journal of Ginseng Research 36 (2012) 354–368.

[3]K.W. Leung, A.S.-T. Wong, Chin. Med. 5 (2010) 20.

[4]J.L. Reay, D.O. Kennedy, A.B. Scholey, J. Psychopharmacol. 19 (2005) 357–365.

[5]J.L. Reay, D.O. Kennedy, A.B. Scholey, J. Psychopharmacol. 20 (2006) 771–781.

[6]S.I. Sünram-Lea, R.J. Birchall, K.A. Wesnes, O. Petrini, Curr. Top. Nutraceutical Res. 3 (2005) 65–74.

[7]D.O. Kennedy, C.F. Haskell, K.A. Wesnes, A.B. Scholey, Pharmacol. Biochem. Behav. 79 (2004) 401–411.

[8]D.O. Kennedy, A.B. Scholey, K.A. Wesnes, Physiol. Behav. 75 (2002) 739–751.

[9]A.B. Scholey, D.O. Kennedy, Hum. Psychopharmacol. 17 (2002) 35–44.

[10]D.O. Kennedy, A.B. Scholey, K.A. Wesnes, Nutr. Neurosci. 4 (2001) 295–310.

[11]L. D’Angelo, R. Grimaldi, M. Caravaggi, M. Marcoli, E. Perucca, S. Lecchini, G.M. Frigo, A. Crema, J. Ethnopharmacol. 16 (1986) 15–22.

[12]Y. Lee, S. Oh, J. Ginseng Res. 39 (2015) 250–256.

[13]M.M. Samira, M.A. Attia, M. Allam, O. Elwan, J. Int. Med. Res. 13 (1985) 342–348.

[14]Y. Li, F. Wang, Y. Luo, J. Surg. Res. 207 (2017) 181–189.

[15]X. Tan, J. Gu, B. Zhao, S. Wang, J. Yuan, C. Wang, J. Chen, J. Liu, L. Feng, X. Jia, J. Ginseng Res. 39 (2015) 116–124.

[16]D. Kim, H. Jeon, S. Ryu, S. Koo, K.-T. Ha, S. Kim, PLoS One 11 (2016) e0164906.

[17]J.M. Van Kampen, D.B. Baranowski, C.A. Shaw, D.G. Kay, Exp. Gerontol. 50 (2014) 95–105.

[18]F. Scaglione, G. Cattaneo, M. Alessandria, R. Cogo, Drugs Exp. Clin. Res. 22 (1996) 65–72.

[19]F.S. Quan, R.W. Compans, Y.-K. Cho, S.-M. Kang, Vaccine 25 (2007) 272–282.

[20]F. Scaglione, K. Weiser, M. Alessandria, Clin. Drug Investig. 21 (2001) 41–45.

[21]J.K. Seida, T. Durec, S. Kuhle, Evid. Based. Complement. Alternat. Med. 2011 (2011) 282151.

[22]J.-W. Jung, H.-R. Kang, G.-E. Ji, M.-S. Park, W.-J. Song, M.-H. Kim, J.-W. Kwon, T.-W. Kim, H.-W. Park, S.-H. Cho, K.-U. Min, Allergy Asthma Immunol. Res. 3 (2011) 103–110.

[23]L.-X. Chen, Y.-L. Qi, Z. Qi, K. Gao, R.-Z. Gong, Z.-J. Shao, S.-X. Liu, S.-S. Li, Y.-S. Sun, Molecules 24 (2019).

[24]M. Takei, E. Tachikawa, A. Umeyama, Biomark. Insights 3 (2008) 269–286.

[25]L.-X. He, J.-W. Ren, R. Liu, Q.-H. Chen, J. Zhao, X. Wu, Z.-F. Zhang, J.-B. Wang, G. Pettinato, Y. Li, Food Funct. 8 (2017) 3523–3532.

[26]Y.H. Jie, S. Cammisuli, M. Baggiolini, Agents Actions 15 (1984) 386–391.

[27]K. Takeda, K. Okumura, Evid. Based. Complement. Alternat. Med. 2015 (2015) 603198.

[28]J.Y. Kim, D.R. Germolec, M.I. Luster, Immunopharmacol. Immunotoxicol. 12 (1990) 257–276.

[29]C.-J. Liou, W.-C. Huang, J. Tseng, Immunopharmacol. Immunotoxicol. 28 (2006) 227–240.

[30]V.K. Singh, S.S. Agarwal, B.M. Gupta, Planta Med. 50 (1984) 462–465.

[31]C.-J. Liou, W.-C. Huang, J. Tseng, Am. J. Chin. Med. 33 (2005) 651–661.

[32]S. Wright, E. Altman, J. Microbiol. Biotechnol. 30 (2020) 101–108.

[33]E.H. Park, J. Yum, K.B. Ku, H.M. Kim, Y.M. Kang, J.C. Kim, J.A. Kim, Y.K. Kang, S.H. Seo, J. Ginseng Res. 38 (2014) 40–46.

[34]Y. Wang, Y.-J. Jung, K.-H. Kim, Y. Kwon, Y.-J. Kim, Z. Zhang, H.-S. Kang, B.-Z. Wang, F.-S. Quan, S.-M. Kang, Viruses 10 (2018).

[35]S.Y. Yin, H.J. Kim, H.-J. Kim, Biol. Pharm. Bull. 36 (2013) 1002–1007.

[36]D.-G. Yoo, M.-C. Kim, M.-K. Park, J.-M. Song, F.-S. Quan, K.-M. Park, Y.-K. Cho, S.-M. Kang, J. Med. Food 15 (2012) 855–862.

[37]D.-G. Yoo, M.-C. Kim, M.-K. Park, K.-M. Park, F.-S. Quan, J.-M. Song, J.J. Wee, B.-Z. Wang, Y.-K. Cho, R.W. Compans, S.-M. Kang, PLoS One 7 (2012) e33678.

[38]J.S. Lee, Y.-N. Lee, Y.-T. Lee, H.S. Hwang, K.-H. Kim, E.-J. Ko, M.-C. Kim, S.-M. Kang, Nutrients 7 (2015) 1021–1036.

[39]J.S. Lee, E.-J. Ko, H.S. Hwang, Y.-N. Lee, Y.-M. Kwon, M.-C. Kim, S.-M. Kang, Int. J. Mol. Med. 34 (2014) 183–190.

[40]M. Sumiyoshi, M. Sakanaka, Y. Kimura, J. Ethnopharmacol. 132 (2010) 206–212.

[41]Y. Sun, S. Chen, R. Wei, X. Xie, C. Wang, S. Fan, X. Zhang, J. Su, J. Liu, W. Jia, X. Wang, Food Funct. 9 (2018) 3547–3556.

[42]J.-I. Lee, K.S. Park, I.-H. Cho, J. Ginseng Res. 43 (2019) 342–348.

[43]J. Kim, H. Byeon, K. Im, H. Min, Food Sci. Biotechnol. 27 (2018) 227–232.

[44]M.J. Lee, M. Jang, J. Choi, B.S. Chang, D.Y. Kim, S.-H. Kim, Y.-S. Kwak, S. Oh, J.-H. Lee, B.-J. Chang, S.-Y. Nah, I.-H. Cho, Mol. Neurobiol. 53 (2016) 1977–2002.

[45]J. Jhun, J. Lee, J.-K. Byun, E.-K. Kim, J.-W. Woo, J.-H. Lee, S.-K. Kwok, J.-H. Ju, K.-S. Park, H.-Y. Kim, S.H. Park, M.-L. Cho, Mediators Inflamm. 2014 (2014) 351856.

[46]G.N. Oh, S.W. Son, J. Ginseng Res. 36 (2012) 391–395.

[47]J.-K. Kim, J.-Y. Kim, S.-E. Jang, M.-S. Choi, H.-M. Jang, H.-H. Yoo, D.-H. Kim, Am. J. Chin. Med. 46 (2018) 1879–1897.

[48]S.B. Heo, S.W. Lim, J.Y. Jhun, M.L. Cho, B.H. Chung, C.W. Yang, J. Ginseng Res. 40 (2016) 18–27.

[49]J. Hao, H. Hu, J. Liu, X. Wang, X. Liu, J. Wang, M. Niu, Y. Zhao, X. Xiao, Evid. Based. Complement. Alternat. Med. 2019 (2019) 3630260.

[50]M. Pannacci, V. Lucini, F. Colleoni, C. Martucci, S. Grosso, P. Sacerdote, F. Scaglione, Brain Behav. Immun. 20 (2006) 546–551.

[51]J. Sun, L. Zhang, J. Zhang, R. Ran, Y. Shao, J. Li, D. Jia, Y. Zhang, M. Zhang, L. Wang, Y. Wang, Int. Immunopharmacol. 58 (2018) 94–102.

[52]H. Mohammadi, A. Hadi, H. Kord-Varkaneh, A. Arab, M. Afshari, A.J.R. Ferguson, E. Ghaedi, Phytother. Res. 33 (2019) 1991–2001.

[53]H.L. Jung, H.E. Kwak, S.S. Kim, Y.C. Kim, C.D. Lee, H.K. Byurn, H.Y. Kang, Am. J. Chin. Med. 39 (2011) 441–450.

[54]M.-Y. Song, B.-S. Kim, H. Kim, J. Ginseng Res. 38 (2014) 106–115.

[55]Sun Y.-F., Zhang X., Wang X.-Y., Jia W., Zhongguo Zhong Yao Za Zhi 43 (2018) 3927–3932.

[56]J.L. Reay, D.O. Kennedy, A.B. Scholey, Br. J. Nutr. 96 (2006) 639–642.

[57]J. Li, D. Cai, X. Yao, Y. Zhang, L. Chen, P. Jing, L. Wang, Y. Wang, Int. J. Mol. Sci. 17 (2016).

[58]S. Park, C.-S. Kim, J. Min, S.H. Lee, Y.-S. Jung, J. Nutr. Sci. Vitaminol. 60 (2014) 159–166.

[59]H.Y. Kim, K.S. Kang, N. Yamabe, T. Yokozawa, Am. J. Chin. Med. 36 (2008) 989–1004.

[60]K.S. Kang, N. Yamabe, H.Y. Kim, J.H. Park, T. Yokozawa, Eur. J. Pharmacol. 591 (2008) 266–272.

[61]E. González-Burgos, C. Fernández-Moriano, R. Lozano, I. Iglesias, M.P. Gómez-Serranillos, Food Chem. Toxicol. 109 (2017) 38–47.

[62]G. Carota, M. Raffaele, V. Sorrenti, L. Salerno, V. Pittalà, S. Intagliata, Fitoterapia 139 (2019) 104370.

[63]L. Liu, M.G. Kelly, E.L. Wierzbicki, I.C. Escober-Nario, M.K. Vollmer, S. Doré, Antioxidants (Basel) 8 (2019).

[64]L. Liu, M.K. Vollmer, A.S. Ahmad, V.M. Fernandez, H. Kim, S. Doré, Free Radic. Biol. Med. 131 (2019) 98–114.

[65]C.Y. Kim, B. Kang, H.J. Suh, H.-S. Choi, Biomed. Pharmacother. 108 (2018) 1507–1516.

[66]C.L.L. Saw, A.Y. Yang, D.C. Cheng, S.S.-S. Boyanapalli, Z.-Y. Su, T.O. Khor, S. Gao, J. Wang, Z.-H. Jiang, A.-N.T. Kong, Chem. Res. Toxicol. 25 (2012) 1574–1580.

[67]H.-H. Park, S.-W. Choi, G.J. Lee, Y.-D. Kim, H.-J. Noh, S.-J. Oh, I. Yoo, Y.-J. Ha, G.-B. Koo, S.-S. Hong, S.W. Kwon, Y.-S. Kim, J. Ginseng Res. 43 (2019) 86–94.

[68]Y. Chung, S. Jeong, H.S. Choi, S. Ro, J.S. Lee, J.K. Park, Anim Cells Syst (Seoul) 22 (2018) 382–389.

[69]Z.-M. Xu, C.-B. Li, Q.-L. Liu, P. Li, H. Yang, Int. J. Mol. Sci. 19 (2018).

[70]P. Zhou, W. Xie, Y. Luo, S. Lu, Z. Dai, R. Wang, X. Zhang, G. Li, G. Sun, X. Sun, Molecules 23 (2018).

[71]X.-Y. Zhang, K. Sun, Q. Zhu, T. Song, Y. Liu, Kaohsiung J. Med. Sci. 33 (2017) 535–542.

[72]P. Wang, C. Lin, S. Wu, K. Huang, Y. Wang, X. Bao, F. Zhang, Z. Huang, H. Teng, Cell. Mol. Neurobiol. 38 (2018) 679–690.

[73]S.W. Lim, L. Jin, K. Luo, J. Jin, C.W. Yang, Lab. Invest. 97 (2017) 1271–1281.

[74]J.-H. Moon, J.-H. Lee, Y.-J. Lee, S.-Y. Park, Oncotarget 7 (2016) 85697–85708.

[75]X. Zheng, W. Chen, H. Hou, J. Li, H. Li, X. Sun, L. Zhao, X. Li, Biomed. Pharmacother. 85 (2017) 620–626.

[76]D.-G. Kim, K.H. Jung, D.-G. Lee, J.-H. Yoon, K.S. Choi, S.W. Kwon, H.-M. Shen, M.J. Morgan, S.-S. Hong, Y.-S. Kim, Oncotarget 5 (2014) 4438–4451.

[77]S.W. Lim, K.C. Doh, L. Jin, J. Jin, S.G. Piao, S.B. Heo, B.H. Chung, C.W. Yang, Nephrology 19 (2014) 490–499.

[78]H.-S. Yoo, J.M. Kim, E. Jo, C.-K. Cho, S.-Y. Lee, H.S. Kang, M.-G. Lee, P.-Y. Yang, I.-S. Jang, Oncol. Rep. 37 (2017) 3287–3296.

[79]Y. Zhang, X. Yang, S. Wang, S. Song, J. Agric. Food Chem. 67 (2019) 10048–10058.

[80]S.J. Shin, S.G. Jeon, J.-I. Kim, Y.-O. Jeong, S. Kim, Y.H. Park, S.-K. Lee, H.H. Park, S.B. Hong, S. Oh, J.-Y. Hwang, H.S. Kim, H. Park, Y. Nam, Y.Y. Lee, J.-J. Kim, S.-H. Park, J.-S. Kim, M. Moon, Int. J. Mol. Sci. 20 (2019).

[81]J.-K. Park, J.-Y. Shim, A.-R. Cho, M.-R. Cho, Y.-J. Lee, J. Med. Food 21 (2018) 544–550.

[82]L. Bao, X. Cai, J. Wang, Y. Zhang, B. Sun, Y. Li, Nutrients 8 (2016).

[83]X.-T. Li, R. Chen, L.-M. Jin, H.-Y. Chen, Am. J. Chin. Med. 37 (2009) 1139–1152.

[84]A.C. Cabral de Oliveira, A.C. Perez, J.G. Prieto, I.D.G. Duarte, A.I. Alvarez, J. Ethnopharmacol. 97 (2005) 211–214.

[85]J. Voces, A.C. Cabral de Oliveira, J.G. Prieto, L. Vila, A.C. Perez, I.D.G. Duarte, A.I. Alvarez, Braz. J. Med. Biol. Res. 37 (2004) 1863–1871.

[86]Y. Fu, L.L. Ji, J. Nutr. 133 (2003) 3603–3609.

[87]C.-S. Kim, K. Jo, J.S. Kim, M.-K. Pyo, J. Kim, BMC Complement. Altern. Med. 17 (2017) 430.

[88]K.S. Kang, J. Ham, Y.-J. Kim, J.H. Park, E.-J. Cho, N. Yamabe, J. Ginseng Res. 37 (2013) 379–388.

[89]H.Y. Quan, D.Y. Kim, S.H. Chung, J. Ginseng Res. 37 (2013) 187–193.

[90]H.Y. Kim, K.S. Kang, N. Yamabe, R. Nagai, T. Yokozawa, J. Agric. Food Chem. 55 (2007) 8491–8497.

[91]K.S. Kang, H.Y. Kim, N. Yamabe, R. Nagai, T. Yokozawa, Biol. Pharm. Bull. 29 (2006) 1678–1684.