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Most polyphenols—fisetin included—are relatively poorly absorbed through the gut barrier. But science has been showing more and more that they can also act locally inside the gut and may exert effects through the gut-brain axis as well. So bioavailability is only part of the potential efficacy equation. Because of this, our science team puts much more weight on scientific studies evaluating body & brain responses over bioavailability. And, big picture, despite evidence suggesting poor bioavailability there are a lot of studies suggesting beneficial support for the brain & body even from poorly absorbed polyphenols. Even with quercetin, most of the senolytic studies to date have been with standard quercetin. We opted for Quercefit® because it was what was used in a human senolytic study, is being investigated in other human senolytic studies, and has been used in human clinical studies in other health areas (so has demonstrated brain & body support benefits)—so Quercefit® has much science behind it in addition to the evidence for its bioavailability.*
The data on the bioavailability of fisetin is a main reason that the Mayo Clinic chose to use a high dose of fisetin in their senolytic studies, and why we are recommending the 1400 mg/day dose of fisetin (which for a person of average weight matches the Mayo dose). In published animal studies of fisetin, oral fisetin in this human-equivalent dose range has supported the management of senescence cells, which is the main outcome we care about (not bioavailability). We think the recommended dose included in Qualia Senolytic is sufficient taking into account the data on fisetin’s low bioavailability, but we would not be as confident that the doses we've seen in other supplements claiming a senescent cell benefit (often 100 mg and sometimes a bit more) would provide the intended support.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Qualia Senolytic is intended to be a great complement to other Qualia products, especially the first product we created in our longevity line, Qualia Mitochondria+. To get the most out of Qualia Mitochondria+ we recommend that you take Qualia Mitochondria+ throughout the month.
Behaviors and strategies that support immune system performance would be expected to also complement senolytics.* We recommend focusing on: (1) Consistently getting enough quality sleep—sleep is a major determinant of how well the immune system performs; (2) Regularly exercising in ways that create fitness—being sedentary and excessive exercise can both weaken immune performance (think Goldilocks principle when it comes to exercise); (3) Managing stress—higher stress is hard on the immune system; and (4) Practicing some type of fasting behavior for several days every three months or so—Valter Longo’s (interviewed on Collective Insight Podcast) fasting-mimicking diet is an example of one of these approaches; it helps rejuvenate immune cells*. And, of course, eating a healthy diet is important for immune system health and complements senolytic supplement protocols.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
The aspects of healthy function that Qualia Senolytic may influence can vary person-to-person: for some people it may be the skin, for other people it may be fat or muscle tissue, for others it could be the brain, joints, immune system, etc. Because of this, there is no one way that Qualia Senolytic is experienced.* With the above in mind, the areas you should expect benefits are the areas that are typically most impacted during aging, so pay attention to signs of healthier skin, muscles, joints and brain functions, as well as overall health and energy, after two-to-three months of taking Qualia Senolytic.*
Some of the potential side effects of taking Qualia Senolytic include light headaches, lack of energy, slight irritability, gastrointestinal disturbances, and other mildly unpleasant symptoms. To mitigate these effects, we recommend eating food and drinking extra water during the two-day Senolytic treatment period.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
We recommend taking all 6 capsules of Qualia Senolytic one day, and the following day, take the other 6 capsules. It doesn't matter if you take them all at once or spread throughout the day.
Our general recommendation is to take Qualia Senolytic with food. The reason for this recommendation is because (1) with food is the most common way senolytics have been used in studies, and (2) Qualia Senolytic contains concentrated food extracts, some of which may be more bioavailable if taken with food.
We would also recommend drinking some extra water during the two day treatment.
Qualia Senolytic is also intended to be a great complement to other Qualia products, especially the first product we created in our Longevity line, Qualia Mitochondria+.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
Qualia Mitochondria+ was formulated to support cells in making energy and keeping healthy cells healthy through the aging process. It's something designed to be taken on most days of the month. Qualia Senolytic was formulated to support pruning away of unhealthy cells as we age. It's something designed to be taken two days a month. We consider them to be perfect complements, with Qualia Senolytic being taken on a couple of the monthly off days from Qualia Mitochondria+.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
Qualia Senolytic should be thought of as a product that pays healthy aging dividends over time and with repeated cycles of use.
In the pilot study we did of Qualia Senolytic prior to bringing it to market, the participants were between the ages of 32 and 66 and had at least a moderate degree of difficulty in comfortably performing a variety of activities of daily living (this is something that frequently accompanies aging).
Most of the participants reported greater ease in comfortably performing these activities and less of the occasional stiffness that can accompany aging after two dosing cycles of Qualia Senolytic (i.e., after taking a full dose of Qualia Senolytic for 2 days, taking a few weeks off, and then taking another full dose of Qualia Senolytic for 2 days).*
While this is one use case, we created a senolytic supplement like Qualia Senolytic to support healthy aging in many areas (brain, muscles, immunity, joint, skin, etc.) so benefits may show up at varying speeds and in a variety of areas of function in different people depending on where aging is taking a toll.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
Yes. While our general recommendation is to take 6 capsules a day on the 2 days a month we recommend that you take Qualia Senolytic, it’s perfectly fine to take a lower dose. But the trade-off of taking a lower dose is getting less senolytic support, which may be just right for a younger, lighter weight, or very healthy adult, but may be sub-optimal support for an older, heavier, or less healthy person, as an example.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease
Intermittent use—some experts call this a “hit and run” approach—is the way senolytic supplements are most commonly used to support healthy aging.* The “hit and run” approach means that senolytics are recommended to be taken for a couple of days followed by a longer period of time when they are not taken.
Senescent cells are created in, and removed from tissues constantly throughout life (and over shorter periods of time like a month). The goal of taking senolytics is to shift the balance in favor of removal, which should not require daily dosing since senescent cells accumulate slowly.*
Think about this “hit and run” dosing as being a bit like how you might approach pruning a plant: pruning is something you’d want to do frequently but not every day. Another way to think about taking senolytics is as being akin to a water fast or detox protocol, which are not something done every day, but instead, would be something done for a few days periodically to support health goals.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
Qualia Senolytic is designed to support healthy aging by targeting and clearing senescent cells—damaged cells that no longer function properly but remain in the body. Benefits may include increased energy, reduced feelings of fatigue, support for tissue repair, and overall rejuvenation. By helping remove these “stagnant” cells, it aims to promote vitality, mobility, and healthier cellular function.*
Foods rich in natural senolytics—compounds that help clear out senescent or “zombie” cells—include those high in fisetin, quercetin, and resveratrol. Examples are berries (like strawberries and blueberries), apples, cruciferous vegetables (such as broccoli and kale), leafy greens, dark chocolate, fatty fish, and plant-based sources like green tea, turmeric, ginger, and long pepper.
However, although there are many different fruits, vegetables, herbs, spices, and other types of foods in the diet that contain senolytic or senomorphic compounds, no food source has been shown to contain senolytics in sufficient amounts for actual senolytic benefits, so far. In other words, in research studies, these compounds showed senolytic action (i.e., they were able to promote the death of senescent cells) only at amounts that are much higher than those available in foods.
By our late 20’s, most of us will begin noticing changes caused by getting older. By our 40’s, we’ve gone beyond noticing …many of us are feeling aspects of the aging process.
Some scientists believe that one of the reasons we notice and feel some aspects of (unhealthy) aging is because of stressed or worn out cells called senescent cells.
Qualia Senolytic was formulated to support tissues in pruning away these senescent cells. Because senescent cells tend to gradually accumulate with the passing of years, senolytic supplements like Qualia Senolytic was created for adults in their 40’s and older or younger adults who may already be noticing or feeling the aging process.*
Qualia Senolytic can also be taken periodically to support adults of all ages in managing senescent cells (AKA zombie cells) as a way to proactively promote healthy aging.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.