Qualia Perimenopause

Qualia Perimenopause was specifically formulated to support temperature regulation during perimenopause.*
Hot flashes arise from changes in three interconnected systems: the hypothalamic receptors that sense hormonal signals, the neural circuits that integrate those signals, and the autonomic nerves that trigger sweating.
Qualia Perimenopause includes three clinically studied ingredients that target each link in this cascade. Menofelis® supports hypothalamic estrogen signaling, black cohosh supports the neural pathways that set thermal tolerance, and γ-oryzanol supports autonomic nervous system balance.

Qualia Perimenopause is specifically formulated to support mental vitality during the menopausal transition.*
For many women, brain fog and forgetfulness during perimenopause are linked to two upstream factors: sleep quality and stress load. When sleep is fragmented and stress circuits remain activated, your focus is usually the first casualty.
That's why Qualia Perimenopause includes ingredients that support restful sleep (chamomile) as well as a healthy stress response (shatavari, Lactobacillus gasseri CP2305), helping build the internal conditions for clearer thinking through perimenopause.*

Qualia Perimenopause is specifically formulated to support restful sleep during the menopausal transition.*
Sleep disruption in perimenopause is mainly driven by two factors. Fluctuating estrogen and falling progesterone weaken the sleep-promoting signals that the brain depends on to fall asleep and stay asleep. At the same time, hot flashes and night sweats can trigger nighttime awakenings — fragmenting sleep even further.
Qualia Perimenopause includes ingredients that address both drivers. Chamomile supports the calming pathways involved in initiating and maintaining sleep, while Lactobacillus gasseri CP2305 supports a shift toward parasympathetic ("rest and digest") activity, which is essential for restorative sleep. Menofelis®, black cohosh, and γ-oryzanol support temperature regulation, which helps prevent night sweats from disturbing sleep.*

Qualia Perimenopause is formulated to support a balanced mood during the menopausal transition.*
Mood swings and irritability in perimenopause are closely tied to hormonal fluctuations. As progesterone declines, the brain’s inhibitory tone — the calming influence that helps buffer stress — takes a hit.
Qualia Perimenopause includes ingredients that support this system from multiple angles. Chamomile supports the calming circuits affected by progesterone decline. Shatavari, a traditional adaptogen, supports the body’s stress response and the neurotransmitter systems involved in mood regulation. Menofelis® has been shown in clinical research to support balanced mood as part of its broader impact on perimenopausal changes.*

Most perimenopause supplements suffer from three problems:
- They lean on ingredients with weak (or non-existent) clinical evidence.
- They use evidence‑backed ingredients, but in non‑standardized forms or at doses well below what was tested.
- They target a single symptom, rather than the systems disrupted by hormonal fluctuations.
Qualia Perimenopause was designed to address all three.
It combines seven clinically studied ingredients, in standardized forms and doses informed by research, which address the major biological systems disrupted during the menopausal transition — including temperature regulation (hot flashes), sleep, mood, stress, gut-brain signaling, and estrogen metabolism.*

Yes. Qualia Perimenopause went through a 28-day in-home user study before launch. After 28 days, overall perimenopause burden fell by ~62%, compared to baseline.†
The ingredients in the formula were also selected based on published clinical research, in the doses and standardized forms shown to be effective in those studies.
† The study was not placebo-controlled and enrolled a relatively small number of participants. Larger controlled studies will be required to confirm the findings. Individual results may vary.

No. Qualia Perimenopause is a hormone-free formula, built from seven science-backed ingredients. It contains no hormones or hormone analogues.
The formula was designed as an alternative approach for the menopausal transition, combining traditional women's health botanicals like shatavari, black cohosh, and Rheum rhaponticum, with modern ingredients like Lactobacillus gasseri CP2305 and DIM. Each ingredient was selected to support the body’s own regulatory systems, rather than replacing hormones or enhancing hormone production.*

Yes. Qualia Perimenopause was formulated for the full arc of the menopausal transition, including the earliest stages when cycles are still regular but symptoms have begun to appear.*
As with any new supplement, we recommend talking to your healthcare practitioner before starting Qualia Perimenopause, especially if you're currently taking medications, have a medical condition, or are pregnant or nursing.*

DIM (3,3'-diindolylmethane) is a bioactive compound derived from cruciferous vegetables, like broccoli and kale. When these vegetables are chopped or chewed, they release indole-3-carbinol (I3C), which is then converted by stomach acid into DIM.*
DIM helps support the body’s natural pathways for processing estrogen, promoting a metabolite profile associated with more efficient deactivation and clearance of the hormone.*
During perimenopause, hormonal output becomes less predictable, with some cycles producing unusually high peaks. How long those signals "echo" in the body depends in part on how estrogen is metabolized. DIM is included in Qualia Perimenopause to support healthy estrogen metabolism during this time.*

Menofelis® is an extract of Siberian rhubarb root (Rheum rhaponticum), standardized to ≥81% hydroxystilbene glycosides — the bioactive compounds that deliver its benefits. It is one of the most extensively researched botanicals for perimenopause.*
It is manufactured to the same standardization as the extract studied in clinical trials under the research designation ERr 731, where it has been shown to support temperature balance, restful sleep, balanced mood, and mental/physical vigor during perimenopause.*

Because the gut-brain axis is an underappreciated lever for perimenopause. The dialogue between the gut and the brain modulates stress response, mood, and sleep — all of which are commonly disrupted during perimenopause.*
Lactobacillus gasser CP2305 is a postbiotic, meaning a heat-inactivated strain of a probiotic originally found in the human gut. Even though the microbes are no longer alive, their cellular components still interact with gut receptors to support stress resilience and sleep quality. CP2305 has been studied specifically in middle-aged women with menopausal complaints, where it was shown to support vasomotor comfort and psychological wellbeing.*