Qualia Stem Cell Proteomics Pilot Study

HOW THE QUALIA STEM CELL PROTEOMICS PILOT STUDY WORKED

Six participants aged 50 - 67 (5 men, 1 woman) were included in this proteomics pilot study. Proteomics is a method of analyzing all of the proteins that cells have made. Proteins can be thought of as the molecules that actually carry out the “work” in the body. This type of analysis actually reflects how cells are responding in real time - or how genetic information is being translated into cellular action. Proteomics (as well as other ‘omics’ technologies like metabolomics, transcriptomics, epigenomics) are now being used as a cutting edge method to investigate the activities and health of stem cells.* 

All participants completed a blood spot test to assess their baseline levels of selected circulating proteins. From Days 1 - 4, participants consumed Qualia Stem Cell daily as indicated on the packaging (6 capsules daily in the morning). Following 4 days of supplementation, participants completed another blood spot test to assess their levels of circulating proteins after supplementation with Qualia Stem Cell.*

The blood spot test is a panel that measures 48 common cytokines. Cytokines are proteins that act as chemical messengers: they help cells communicate with one another and coordinate responses. While not all of them play major roles in stem cell biology, roughly a dozen were more strongly implicated.*

With only six participants, the sample size is too small to draw meaningful statistical conclusions, especially for something as biologically variable as stem cell related signaling, where each person likely has their own unique pattern or signature. Because of that, it made more sense to compare each individual to their own baseline rather than analyze the results as a whole group.* 

RESULT HIGHLIGHTS

Qualia Stem Cell supported individual levels of key stem cell biomarkers^‡*

In our oldest participant (aged 67), their circulating levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) increased by 770% after taking Qualia Stem Cell compared to baseline, which was one of the biggest responses we saw in the study. This cytokine was one of the main stem cell mechanisms we targeted with ingredients in our formula, and is largely known to help stem cells get to where they need to go (migration), and to support them in becoming their target cell type (differentiation).* 

We also observed 2 participants had increased levels of the cytokine CXC motif chemokine 12 (CXCL12, also known as SDF-1) that is involved in the CXCR4/SDF-1 pathway, another main stem cell mechanism we had targeted with ingredients in our formula. Increases in this cytokine might suggest stem cells are more able to leave the bone marrow (mobilize) and travel to target tissues (migrate). These two participants' levels of CXCL12 were boosted by 132% and 324%, respectively, after 4 days of Qualia Stem Cell.* 

The largest effect we saw was in one participant, whose interleukin-10 (IL-10) levels increased by 9300%, which is a cytokine that promotes healthy inflammatory processes and can directly stimulate the stem cell’s ability to preserve and heal itself (self-renewal and regeneration). These findings are exploratory only, and conclusions can not yet be drawn regarding therapeutic outcomes.*

Qualia Stem Cell supports changes in cytokines that participate in stem cell activity^‡*

In addition to looking at changes in individual biomarkers, we explored the “signature” or “profile” of changes among each individual comparing baseline to after Qualia Stem Cell supplementation. In our oldest participant (aged 67), for example, the most notable changes in cytokines were the following: a 2872% increase in IL17F, a 903% increase in IL2, a 770% increase in GM-CSF, a 387% increase in IL27, a 202% increase in IL-10, a 143% increase in IL7, a 132% increase CXCL12 and a 121% increase in IFN-γ. Overall, these changes in cytokines suggest shifts in signaling across pathways that may influence how stem cells move and function. The changes were broad and mixed, involving signals that can affect several pathways rather than pointing in a single clear direction. The meaning of these changes for long-term health isn’t clear yet, but they are promising for helping us understand how Qualia Stem Cell might influence stem cell related signaling and for guiding the design of future studies.*

DISCUSSION

Overall, among all participants we observed broad and complex shifts in cytokine signaling following Qualia Stem Cell supplementation, along with encouraging changes in several key stem cell related markers. However, because the timing and sequence of stem cell activation steps in humans aren’t well mapped yet, future studies with more participants and more frequent time points will be essential to capture and understand those dynamics more clearly.*

^‡Disclaimer: Although these results are encouraging, these findings are not statistically significant and the study was not placebo-controlled. Larger, controlled studies will be required to confirm the findings.

*These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure or prevent any disease. The information on this site is for educational purposes only and should not be considered medical advice. Please speak with an appropriate healthcare professional when evaluating any wellness related therapy. Please read the full medical disclaimer before taking any of the products offered on this site.