Happy to help. We recommend taking all 6 capsules of Qualia Senolytic one day, and take the remaining 6 capsules on the following day once a month. While there are no special instructions for getting started, a good way to introduce anything new is to start small and increase over time. Rather than taking the full recommended dose of 6 capsules a day on 2 back-to-back days during the first month, it’s fine to start by taking a lower dose and spreading it out over a few more days, or to start at a lower dose and eventually build up to the recommended dose. Our general recommendation is to take Qualia Senolytic with food. The reason for this recommendation is because (1) with food is the most common way senolytics have been used in studies, and (2) Qualia Senolytic contains concentrated food extracts, some of which may be more bioavailable if taken with food.