Adaptogen

American Ginseng (Panax quinquefolius) Root Extract

American ginseng (Panax quinquefolius) is a variety of ginseng native to forested regions in North America. It is the same genus as Asian ginseng (Panax ginseng) and prized for many of the same reasons—invigorating and fortifying in times of higher stress or greater demands, and for supporting the capacity for mental and physical work. Both American and Asian ginseng contain similar active constituents called ginsenosides. The ginsenosides are thought to be responsible for many of the adaptogenic (i.e., stress and fatigue support) and health-promoting properties associated with ginseng [1]. While there are many different ginsenosides, the most well characterized include Rb1, Rb2, Rg1, Rc, Rd, and Re. 

TOP BENEFITS OF AMERICAN GINSENG

Supports brain health and cognitive performance*

Supports adaptation to stress *

Supports mood*

QUALIA’S AMERICAN GINSENG SOURCING

American Ginseng Root Extract is standardized for 5% ginsenosides.

American Ginseng Root Extract is non-GMO, gluten-free, and vegan.

AMERICAN GINSENG FORMULATING PRINCIPLES AND RATIONALE

We consider Panax quinquefolius to be in the adaptogenic herb category; following hormetic dosing principles (see Qualia Dosing Principles) with a high likelihood of having a hormetic range (i.e., a dosing range below and above which results could be poorer). We have selected a serving that is consistent with those used in human clinical studies for supporting working memory, alertness, and calmness.*

AMERICAN GINSENG KEY MECHANISMS

Supports brain function and cognition*

Supports attention* [2]

Supports working memory* [2,3]

Supports learning and memory (in animals)* [4–7]

Supports cholinergic neurotransmission* [1,4,5,8,9]

Supports dopaminergic neurotransmission* [10–13]

Supports GABAergic neurotransmission* [1,14]

Supports neurite outgrowth, dendritic spine density, and synaptic plasticity* [1,5–7]

Supports BDNF signaling* [1,7,8,15]

Supports neurogenesis (in animals)* [1,8,15] 

Supports neuroprotective functions* [1,4,5,8,14,16]

Supports antioxidant defenses and counters oxidative stress* [14]

Supports healthy neural immune/cytokine signaling* [1,8,14,17]

Supports mood*

Supports calmness* [2]

Supports mood* [1,14,18]

Adaptogenic actions (i.e., supports stress resilience and anti-fatigue)* [5]

Modulates stress hormone levels / HPA-axis activation* [1,14] 

Supports healthy cardiometabolic function*

Supports healthy cardiometabolic parameters* [19–21]

Supports healthy blood glucose levels* [22–24]

Supports fat metabolism* [21]

Supports mitochondrial enzyme complex activities* [14]

Supports a healthy gut microbiota*

Supports healthy gut microbiota composition* [25–27]

Supports healthy gut immune/cytokine signaling* [25,26,28]

Supports gut-brain axis* [29]

Supports exercise performance*

Supports high-intensity endurance performance* [30,31]

Supports healthy responses to exercise-induced muscle damage* [30–32]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES 

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Schisandra chinensis Fruit Extract

The fruits of Schisandra chinensis are berries. They are one of the 50 fundamental herbs in Traditional Chinese Medicine, and have been used in traditional medicine in Japan, Korea, and Far East regions of the Russian empire. One of its common names—Five-Flavor-Fruit—is because the berries are known for possessing all five basic flavors: salty, sweet, sour, pungent (spicy), and bitter. S. chinensis fruits are considered to be an adaptogen, supporting broad resistance to stress, mental and physical performance, mood, sleep, vision, and immunity. This broad stress-adaptability story fits with emerging research on how green spaces restore attention and boost creativity, suggesting that both internal and environmental inputs can work together to support resilience. 

Several of its traditional uses, including use as a tonic to counter exhaustion and support night vision, led to Russian scientists extensively studying the berries and seeds in both animals and humans from 1940-1960. As a result of this research S. chinensis gained recognition as an adaptogen in the early 1960’s in the former USSR, and has continued to be extensively studied in articles published in Russian, and more recently in English language journals. The primary active compounds in S. chinensis berries are schisandra lignans—lignans are a subgroup of non-flavonoid polyphenols that interact with gut microbiota (i.e., gut-brain axis) [1].*

TOP BENEFITS OF SCHISANDRA CHINENSIS

Supports brain function*
Supports mood*
Supports resistance to stress*
Supports endurance capacity*
Supports sleep*

QUALIA’S SCHISANDRA CHINENSIS SOURCING

Schisandra chinensis fruit extract is standardized to contain not less than 9% schisandrins.

Schisandra chinensis fruit extract is Non-GMO and Vegan.

SCHISANDRA CHINENSIS FORMULATING PRINCIPLES AND RATIONALE

The original Russian research resulted in Schisandra chinensis being categorized as an herbal adaptogen. Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response (see Qualia Dosing Principles). It’s important to be in this zone; it’s just as important not to be above it. The Russian research also found that the amount of the schisandra lignans given was critical when determining the serving, with very low amounts of these compounds being nootropic and ergogenic. So, when an extract is standardized for higher amounts of schisandrins, lower amounts of it should be taken. Our serving of S. chinensis is determined based on the standardization in order to provide an amount of schisandra lignans in the target range for a healthy adaptive response.*

SCHISANDRA CHINENSIS KEY MECHANISMS

Adaptogenic actions*

Supports endurance and working capacity* [1]

Supports resistance to stress* [1–8]

Supports healthy behavioral responses to stress* [3,4,7]

Supports a calm mood* [1,9]

Supports sleep* [1]

Supports brain function*

Supports mental performance* [1]

Supports healthy vision* [1]

Supports learning and memory in animals* [7,10–13]

Supports GABAergic neurotransmission* [3,14,15]

Supports GABA-Glutamate levels* [10,11,15,16]

Supports acetylcholine signaling* [10,11,13]

Supports serotonin signaling* [9–11,16]

Supports adrenergic signaling* [9–11,16]

Supports dopamine signaling* [9–11,16]

Supports sleep mechanisms* [14,15,17,18] 

Supports brain-derived neurotrophic factor (BDNF)* [4,7]

Supports neuroprotective functions* [10–13,19,20]

Supports brain mitochondrial function* [21]

Supports antioxidant defenses* [10,19,21,22]

Supports phase II detoxifying/antioxidant enzymes* [22]

Supports a healthy gut microbiota*

Supports a healthy gut microbiota composition* [23,24]

Supports gut microbial metabolism* [24]

Supports gut immune responses* [24]

Supports healthy immune function*

Supports innate immunity* [25–27]

Supports immune function during some forms of stress* [2,28–30]

Supports immunomodulation (i.e., balance of immune function)* [31–33]

Promotes healthy aging and longevity*

Supports mitochondrial function* [19,21,34]

Supports antioxidant defenses* [21,34]

Supports autophagy* [35]

Supports healthy muscle and bone with aging* [36,37]

Complementary ingredients*

Sesamin (from sesame seeds)—another lignan—to support liver health [38] and blood fluidity* [39]

Other adaptogens (e.g., Rhodiola, Siberian Ginseng) as a nootropic and immune support* [40,41]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES 

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KSM-66 Ashwagandha®​ (​Withania somnifera​) Root Extract

KSM-66 Ashwagandha^® is a full-spectrum ashwagandha root extract. Ashwagandha (i.e., Indian ginseng) is a Rasayana—the category of elixirs and tonic herbs prized by the branch of Ayurvedic medicine concerned with rejuvenation and focused on promoting a youthful state of physical and mental health. Ashwagandha holds a prominent place among the Rasayana herbs, where it was used for many reasons including as general tonic and to infuse energy and vigor in circumstances characterized by exhaustion or a lack of physical energy. A key attribute is that ashwagandha promotes balance. As the English name Indian ginseng implies, ashwagandha was believed to share some of the attributes of ginseng, in essence supporting multiple areas of health and well-being, especially under conditions characterized by increased stress. Herbs that produce these types of nonspecific resistance to and recovery from stress—and which typically also support general well-being, healthy energy, and homeostasis—are called adaptogens. Among its studied benefits, ashwagandha supports sleep quality, relaxation, muscle recovery, cognitive function, immunity and a healthier stress response.*

TOP BENEFITS OF KSM-66 ASHWAGANDHA®

Supports sleep*

Supports healthy stress resistance*

Supports cognitive performance*

QUALIA’S KSM-66 ASHWAGANDHA^® SOURCING

KSM-66 Ashwagandha® was the product of 14 years of R&D. It is the most researched brand of ashwagandha, with a research focus on what happens in healthy people when they take the ingredient.

Created by Ixoreal Biomed Inc., the world's ashwagandha experts. Ixoreal owns the entire production chain from farm to the finished ingredient, allowing them to deliver high-quality ashwagandha with batch-to-batch consistency.

KSM-66 Ashwagandha^® is a “full-spectrum” root extract, which means it is designed to maintain the balance of the various constituents found in the root. It is standardized for ≥5% withanolides and <0.1% withaferin A.

KSM-66 Ashwagandha^® has won awards as an innovative ingredient and for sports nutrition. It has also qualified for an extensive number of certifications including Organic, Non-GMO, GRAS, Vegan and Gluten-Free.

KSM-66 Ashwagandha® is a registered trademark of Ixoreal Biomed Inc.

KSM-66 ASHWAGANDHA^® FORMULATING PRINCIPLES AND RATIONALE

We consider Withania somnifera (i.e., ashwagandha) to be an herbal adaptogen, so expect it to follow hormetic dosing principles. Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. Based on studies where different doses have been given in the same study, we also consider ashwagandha dosing to be somewhat akin to the Pareto Principle (i.e., 80-20 rule), because much of the benefits have occurred at a lower dose, and relatively modest additional gains are achieved at doses two- to four-fold higher (see Qualia Dosing Principles). Because of both of these reasons, it’s important to identify the lowest dose that can produce many of the desired responses when using ashwagandha. Since we also use ashwagandha in more than one product, it’s also important to us to ensure that a user taking several of our products will not inadvertently take too much ashwagandha. The most common dose of KSM-66 Ashwagandha^® in human studies has been 300 mg taken twice a day (i.e., 600 mg a day total). We consider this to be the upper end of the total amount of daily ashwagandha that we’d want a customer to take over a long period of time, and 300 mg to be the maximum at a given time of day (i.e., if being taken at dinner as an example). We consider the lower end of the beneficial range to be about 125-150 mg depending on the ashwagandha extract being used.*

WITHANIA SOMNIFERA KEY MECHANISMS

Promotes healthy sleep*

Supports sleep onset and total sleep time* [1,2]

Supports sleep efficiency* [1]

Supports quality of sleep* [1,3]

Supports slow wave sleep* [2]

Supports healthy mood and stress response*

Supports a calm mood* [1,4,5]

Supports healthy stress responses* [6–8]

Supports healthy stress hormone levels* [4,6–8]

Supports brain function*

Supports cognitive performance* [9–11]

Supports GABA signaling* [2,12–15]

Supports dopamine signaling* [16]

Influences acetylcholinesterase activity* [16]

Supports neuroprotective functions* [16–19]

Influences neural immune signaling* [5,19]

Supports healthy immune system function*

Supports innate immunity* [20–24]

Supports adaptive immunity* [20,21,24–33]

Supports immune system communication* [24,34–36]

Supports healthy immune signaling* [5,37,38]

Supports mitochondrial structure and function*

Supports mitochondrial function and structure [18,39]

Supports electron transport chain activity [16–18,40]

Supports citric acid cycle enzymes [40]

Promotes exercise performance*

Supports endurance performance* [41,42]

Supports muscle strength* [3,43]

Supports post-exercise recovery* [43]

Supports healthy metabolism*

Supports healthy blood glucose levels* [37,38,44–48]

Supports healthy leptin signaling* [5,47]

Supports healthy feeding behaviors* [5,6]

Supports lean mass* [43]

Enhances antioxidant defenses*

Supports antioxidant defenses* [16–18,48,49]

Replenishes glutathione (GSH) levels* [16,18,48]

Counters ROS levels and oxidative stress* [16,18,19,39]

Supports healthy thyroid function*

Supports thyroid function* [50–52]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

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Panax ginseng Root Extract

The roots of Panax ginseng (Korean ginseng, Asian ginseng) have been used for thousands of years in China, Korea, and Japan. In these traditions, it was used as a Qi tonic to promote strength, restore vitality, support energy, and to quiet the spirit. “Panax” means “all-healing” in Greek. It is aptly named, based on both its traditional uses and modern scientific research [1]. P. ginseng is characterized as an adaptogen—it is used for invigorating and fortifying in times of higher stress or greater demands. P. ginseng is also used to support the capacity for mental and physical work. A great deal of research on P. ginseng has been related to the immune system, where it acts as an immune adaptogen, supporting both the innate and adaptive immune systems [2]. The main bioactive compounds of Panax ginseng are ginsenosides [3].*

TOP BENEFITS OF PANAX GINSENG ROOT EXTRACT

Supports cognitive function*

Supports general immune health*

Supports upper respiratory health*

QUALIA’S PANAX GINSENG  ROOT EXTRACT SOURCING

Panax ginseng Root Extract is made from dried roots. 

Panax ginseng Root Extract is standardized to contain not less than 4% ginsenosides.

Panax ginseng Root Extract is non-GMO, Halal, Kosher, gluten-free and vegan.

PANAX GINSENG  ROOT EXTRACT DOSING PRINCIPLES AND RATIONALE

Because Panax ginseng is an adaptogen, we consider dosing to follow hormetic principles (see Qualia Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone. The established daily dose range for Panax ginseng root extracts standardized for 4% ginsenosides is 40-200 mg. Our dosage is consistent with this established dosage range.*

PANAX GINSENG KEY MECHANISMS

Supports brain function*

Supports cognitive performance* [4–12]

Supports resistance to mental fatigue* [4,5]

Supports brain metabolism* [13]

Supports neuroprotective functions* [14–17]

Supports healthy immune function* 

Supports general immune health* [18–22]

Supports innate immunity* [18,23–30]

Supports adaptive immunity* [18,19,23–26,29–31]

Supports cellular intrinsic immune defenses* [32–39] 

Supports mucosal immunity* [40,41]

Supports immune tolerance* [42–48] 

Supports immune cell function* [18,19,23–31,49] 

Supports immune signaling* [19,23,25,41,50–53]

Supports immune organ function* [51]

Promotes healthy aging and general well-being*

Supports a healthy gut microbiota* [41,54,55]

Supports healthy blood glucose levels* [4,5,56]

Supports antioxidant defenses* [15,51,57–61]

Supports Nrf2 signaling and phase II detox enzymes* [12,23,62–66]

Supports autophagy* [14,67–77]

Supports AMPK signaling* [68,78]

Supports mitochondrial function* [61,74,79–86]

Modulates advanced glycation end product (AGE) production* [57,59,60,87–91]

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.

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Sirtmax® Kaempferia parviflora

Kaempferia parviflora is found in the upper Northeastern regions of Thailand. Root extracts have a long history of use and a reputation for being a health tonic and energy enhancer (i.e., Thai ginseng). The novel active constituents are a special type of polyphenol called polymethoxyflavonoids. Sirtmax^® Kaempferia parviflora root extract is standardized for polymethoxyflavonoid content.*

Top Benefits of Sirtmax®

Supports healthy aging*

Supports mitochondrial function*

Supports muscle strength and endurance*

Supports antioxidant defenses*

Qualia’s Sirtmax^® Sourcing

Sirtmax^® has been used in animal and human research studies.

Created by Tokiwa Phytochemicals, a leader in standardized Kaempferia parviflora supplementation. 

Highest concentration, full-spectrum root extract, with triple standardization for 5,7-dimethoxyflavone (≥ 4%), 3, 5, 7, 3', 4'-pentamethoxyflavone (≥ 3.5%), and total polymethoxyflavonoids (≥ 15%).

Grown in Thailand & Laos.

Sirtmax^® is a registered trademark of Tokiwa Phytochemical Co., Ltd.

Sirtmax^® Formulating Principles and Rationale

We consider Kaempferia parviflora to be in the adaptogenic herb category; following hormetic dosing principles (see Qualia Dosing Principles) with a high likelihood of having a hormetic range (i.e., a serving range below and above which results could be poorer). We have selected a serving that is within the studied range in humans.*

Kaempferia parviflora Key Mechanisms

Supports mitochondrial structure and function*

Supports transcription factors of mitochondrial biogenesis (PGC-1α, ERRα, NRF1, TFAM)* [1–3]

Supports mitochondrial number* [1]

Supports ATP production* [3]

Promotes β-oxidation (fatty acid metabolism) – upregulates PPARγ and PPARδ*  [2,4]

Promotes exercise performance*

Supports endurance performance* [1,2,5,6]

Supports post-exercise recovery* [1]

Supports muscle strength* [5,6]

Supports muscle metabolism* [1]

Supports healthy metabolic function*

Supports healthy fat accumulation and blood/liver lipid levels* [4,7,8]

Promotes differentiation of brown adipocyte cells* [4]

Supports UCP1 and thermogenesis of brown adipose tissue* [4,7,8]

Promotes whole-body energy expenditure through activation of brown adipose tissue* [7,9]

Promotes lean body mass* [2]

Promotes healthy aging and longevity* 

Supports neuroprotective functions* [10]

Counters the production of advanced glycation end-products (AGEs)* [11]

Promotes healthy cardiovascular NO signaling and vasodilation* [12–15]

Supports antioxidant enzymes* [5]

Supports AMPK signaling* [2,3]

Supports SIRT-1 signaling* [2,11]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

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Rhodiola rosea Root Extract

Scientific Name:
Rhodiola rosea

Sensoril® Ashwagandha Withania somnifera Root and Leaf Extract

Ashwagandha is an Ayurvedic herb with adaptogenic properties—it’s often referred to as “Indian ginseng.” Ashwagandha has a long history of use and has been reported to have several health-promoting effects, supporting healthy energy, metabolism, stress response, physical performance, sleep, joint health, and cognitive performance. The novel active constituents are a group of plant compounds called withanolide glycosides. Sensoril® root and leaf extract is standardized for withanolide glycoside content.*

Top Benefits of Sensoril® Ashwagandha

Supports mitochondrial function* 

Supports exercise performance*

Supports healthy stress resistance*

Supports cognitive performance*

Supports sleep*

Qualia’s Sensoril^® Ashwagandha Sourcing

Sensoril^® has been clinically tested in 10 randomized, double-blind, placebo-controlled human trials.

Created by Natreon Inc., a leader in scientifically studied and tested Ayurvedic ingredients.

Leaf and root extract triple standardized to contain a minimum of 10% withanolide glycosides, the main bioactive; a minimum of 32% oligosaccharides, which increase the bioavailability of the withanolide glycosides; and a maximum of 0.5% free withanolides (as Withaferin A).

Protected by multiple U.S. patents with self-affirmed generally recognized as safe (GRAS) status). 

Sensoril^® is vegan, non-GMO, gluten-free, Kosher and Halal certified.

Sensoril^® Ashwagandha Formulating Principles and Rationale

We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Qualia Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest amount that can produce the desired response. Sensoril®—the standardized extract we use—produced a threshold response in a study that gave different daily dosages—125 mg, 250 mg, 500 mg. Effect size was slightly greater for the higher doses, but most of the change was evident with the lowest dose [1]. We opted for this lower serving to be consistent with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.*

Withania somnifera Key Mechanisms 

Supports mitochondrial structure and function*

Supports mitochondrial function and structure* [2,3]

Supports electron transport chain activity* [2,4–6]

Supports citric acid cycle enzymes* [6]

Promotes exercise performance*

Supports endurance performance* [7,8]

Supports muscle strength* [9,10]

Supports post-exercise recovery* [10]

Supports healthy metabolism*

Supports healthy blood glucose levels* [11–17]

Supports healthy leptin signaling* [16,18]

Supports healthy feeding behaviors* [18,19]

Supports lean mass* [10]

Enhances antioxidant defenses*

Supports antioxidant defenses* [2,4,5,17,20]

Replenishes glutathione (GSH) levels* [2,4,17]

Counters ROS levels and oxidative stress* [2–4,21]

Supports brain function*

Supports cognitive performance* [22–24]

Supports GABA signaling* [25–29]

Supports dopamine signaling* [4]

Influences acetylcholinesterase activity* [4]

Supports neuroprotective functions* [2,4,5,21]

Influences neural immune signaling* [18,21]

Promotes healthy sleep*

Supports sleep onset and total sleep time* [28,30]

Supports sleep efficiency* [30]

Supports quality of sleep* [9,30]

Supports slow wave sleep* [28]

Supports healthy mood and stress response*

Supports a calm mood* [18,30,31]

Supports healthy stress responses* [1,19,32]

Supports healthy stress hormone levels* [1,19,31,32]

Supports healthy immune system function*

Supports innate immunity* [33–37]

Supports adaptive immunity* [33,34,37–46]

Supports immune system communication* [37,47–49]

Supports healthy immune signaling* [13,14,18]

Supports healthy thyroid function*

Supports thyroid function [50–52]

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.

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Senactiv®

Senactiv^® (previously called ActiGin) is a patented combination of two adaptogenic extracts—notoginseng root (Panax notoginseng, aka san-chi ginseng) and sweet chestnut rose fruits (Rosa roxburghii). Both extracts have a long history of use in Traditional Chinese Medicine. Notoginseng is rich in bioactive compounds common to plants in the ginseng family, namely polysaccharides and saponins. Ginsenosides are the main saponins in notoginseng, with Ginsenoside Rg1 being one of the most abundant ginsenosides in notoginseng. R. roxburghii is native to the southwest region of China. It is known for its high vitamin C, superoxide dismutase (SOD), and flavonoid content. R. roxburghii has strong antioxidant properties. Senactiv® is the result of more than 10 years of research and development. It has been used in 5 human studies, with more studies in the pipeline. The emphasis of the studies has been on exercise performance, especially in functions related to muscle energy, recovery, and senescent cells.* 

TOP BENEFITS OF SENACTIV^®

Supports exercise performance*

Supports healthy aging *

Supports cellular health *

QUALIA’S SENACTIV^® SOURCING

Senactiv^® is a patented ingredient made from highly purified and fractionated extracts of Panax notoginseng and Rosa roxburghii. It is produced by NuLiv Science.

Senactiv^® is standardized to contain not less than 30% saponins, including not less than 10% ginsenoside Rg1. It’s also standardized for polyphenols (≥2%) and vitamin C (≥0.6%).

Senactiv^® is a registered trademark of NuLiv Science USA Inc.

Senactiv^® is non-GMO, gluten-free, vegan. It is Informed Choice Ingredient and Informed Sport Certified, Kosher certified, and Halal certified. 

SENACTIV^® FORMULATING PRINCIPLES AND RATIONALE

In human and animal research studies, rather than seeing Senactive^® mentioned by name, you’ll see Rg1 supplied by NuLiv Science, Inc., Brea, CA, USA. The amount of Rg1 used in the human studies has been 5 mg [1–5], while we are recommending a 50 mg serving of Senactive^®. This can be a bit confusing. The makers of Senactive^® began studying this extract before they decided on this trademarked name. So, when they submitted articles to scientific journals for publication, they referred to it by one of the compounds used to standardize the extract, specifically the Rg1 from the Panax notoginseng (some journals also prefer trademarked names not be used). The key point is that we are using the extract from these studies at the studied serving, with 50 mg of SenActiv® providing the 5 mg ginsenoside Rg1 mentioned in the studies.* 

SENACTIV^® KEY MECHANISMS

Supports brain function*

Supports cognitive function (in animals)* [6,7]

Supports neuroprotective functions* [8–14]

Supports synaptic plasticity* [6,7]

Influences neural autophagy* [10]

Influences microglia activation and neural immune signaling* [15]

Supports neural stem cell function* [12,16,17]

Counters neural senescence* [13]

Promotes exercise performance*

Supports exercise performance* [1,2,18]

Supports exercise recovery* [1]

Supports skeletal muscle metabolism* [1]

Counters exercise-induced oxidative stress* [1,19,20]

Supports healthy skeletal muscle immune signaling* [1]

Supports the elimination of senescent cells in exercising muscle* [2] 

Supports a healthy gut microbiota*

Supports healthy gut microbiota composition* [21–23]

Supports the gut-brain axis* [23]

Promotes healthy aging* 

Supports antioxidant defenses* [24–29]

Supports autophagy* [8,30–34]

Supports mitochondrial function* [35]

Influences advanced glycation end product (AGE) production* [25]

Supports the management of senescent cells* [2] 

Supports anti-senescence mechanisms* [36–44]

Supports stem cell health* [5,25,39,42,43,45,46]

Supports cellular functions involved with pruning stressed cells* [47,48]

Supports cellular signaling* 

Influences PI3K/AKT* [36,49,50]

Influences mTOR signaling* [34,36,50]

Influences AMPK signaling* [34,51–53]

Influences SIRT1 signaling* [48,54,55]

Influences Nrf2 signaling* [49,56–60]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Holy Basil (Ocimum sanctum) Leaf Extract

Holy Basil (Ocimum sanctum; synonym Ocimum tenuiflorum) is a culinary and medicinal aromatic herb that has been used within Ayurvedic medicine for more than 3000 years [1]. In Ayurvedic medicine holy basil is called “tulsi,” which translates as “the incomparable one.” It is one of a small number of herbs categorized as Rasayana, the category applied to elixirs and tonic herbs prized for rejuvenation and revitalization. It was believed to guard the body from stress of all types while keeping the mind sharp and the body healthy. In modern times, holy basil is categorized as an adaptogen, supporting a healthy stress response. Holy basil also supports mood, cognition and immunity. Holy basil’s bioactive molecules include ursolic acid, rosmarinic acid, eugenol, ocimumosides A and B, ocimarin, apigenin and lutein [2,3].

TOP BENEFITS OF HOLY BASIL

Supports a calm mood*

Supports cognitive function*

Support healthy stress responses*

Supports general immune health*

QUALIA’S HOLY BASIL SOURCING

Holy Basil is a leaf extract standardized to contain not less than 2% ursolic acid.

Holy Basil is Non-GMO and Vegan.

HOLY BASIL FORMULATING PRINCIPLES AND RATIONALE

Because holy basil is an Ayurvedic Rasayana herb, we consider dosing to follow hormetic principles similar to herbal adaptogens (see Qualia Dosing Principles ). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. For herbs that are adaptogens, especially when they will be used for extended periods of time, we think it’s important to identify the lowest amount that can produce many of the desired responses. Different amounts of holy basil have been used in human studies. Functional benefits have occurred at low amounts (~300mg) and at amounts four-fold higher (1200mg). Considered collectively, human studies suggest holy basil dosing may be somewhat akin to the Pareto Principle (i.e., 80-20 rule), where 80%+ of the benefits happen at 20% of the dose. Our goal with holy basil, as with all ingredient choices, is to select the appropriate serving keeping in mind both the ingredient and the other ingredients being used in a formulation. In other words, if we are also supplying other adaptogen extracts, we are likely to use less holy basil than if the only herbal adaptogen we were using was holy basil.*

HOLY BASIL KEY MECHANISMS

Supports healthy mood and stress responses*

Supports a calm mood* [4–11]

Supports a positive mental-emotional bias* [6,9]

Supports healthy stress hormone levels* [4,7,8,12,13]

Supports brain function*

Supports memory and learning* [5,14,15]

Supports working memory* [4]

Supports executive function* [4]

Supports attention* [6]

Supports sleep* [5]

Supports serotonin signaling* [16–18]

Supports dopamine signaling* [16–18]

Supports adrenergic signaling* [17,18]

Supports acetylcholine signaling* [14,19–21]

Influences acetylcholinesterase (AChE) activity* [19,22]

Supports brain antioxidant defenses* [18,23–25]

Supports neuroprotective functions* [15,18,23–27]

Supports healthy immune system function*

Supports innate immunity* [28]

Supports adaptive immunity* [28–31]

Promotes general health and wellbeing*

Supports gastroprotective functions* [32,33]

Supports healthy metabolism* [34,35]  

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Longvida® Optimized Curcumin® Extract (from Curcuma longa Root)

Longvida^® was developed by university neuroscientists to overcome issues with the low bioavailability of curcumin [1] and is trademarked as “the Cognitive Curcumin of Choice^®” and as “Longvida Optimized Curcumin^®.” Curcumin comes from turmeric (Curcuma longa rhizome, a plant from the ginger family), is the pigment that gives turmeric its characteristic yellow-orange color, and is why turmeric is sometimes referred to as “yellow root” or “golden spice.” Turmeric is widely used as a food spice, especially in South Asia, and has been used in Ayurveda traditional medicine for thousands of years. Longvida® has been clinically studied to support a number of health applications, including, but not limited to, cognitive health, retinal health, vascular health, exercise recovery, sports nutrition, joint health, healthy aging, immune health, and adaptogenic properties.* 

TOP BENEFITS OF LONGVIDA^®

Supports cognitive function *

Supports exercise recovery *

Supports healthy vision *

QUALIA’S LONGVIDA^® SOURCING

Longvida^® is a patented turmeric extract standardized to deliver free curcumin to target tissues, including the brain.*

Longvida^® has been used in human clinical studies. It has been a finalist and winner of several awards for outstanding research initiatives. 

Longvida^®️ and Optimized Curcumin^®️ are registered trademarks of Verdure Sciences, Inc. Patents: www.vs-corp.com/ip.html

Longvida^® is non-GMO, gluten-free, and vegan.

LONGVIDA^® FORMULATING PRINCIPLES AND RATIONALE

In human studies, the dose of Longvida^® has ranged from 400 mg to 2000 mg/day [2–5], with cognitive studies emphasizing a 400 mg serving, while joint health and exercise recovery have used 800 mg. Our recommended serving was selected to be within the studied range, taking into consideration any complementary features of other ingredients in the formulation and the intended benefits and use of the formula. 

CURCUMIN KEY MECHANISMS

Supports brain function*

Supports working memory (in older individuals)* [2,3]

Supports memory* [6]

Supports attention* [2,6]

Supports cognitive function (in animals)* [7–16]

Supports neuroprotective functions* [6,17,18]

Supports antioxidant defenses and counters oxidative stress* [7,9,10,15,19,20]

Supports dendritic spine density and dendritic length* [12]

Supports brain-derived neurotrophic factor (BDNF) signaling* [15]

Supports long-term potentiation (LTP)* [21]

Supports brain NF-κB and immune signaling* [9,22–24]

Supports neural mitophagy and mitochondrial function* [25,26]

Supports neuronal autophagy* [27–29]

Counters age-related changes in clock gene rhythms in the SCN* [30]

Supports a healthy mood *

Supports positive affect* [31–33]

Supports calm and relaxed mood* [2,32]

Supports visual health* 

Supports visual function* [34–37]

Supports healthy retinal function* [35,37–40]

Supports blue light defenses* [38]

Supports ocular antioxidant defenses and couters oxidative stress* [39,41]

Supports healthy retinal vasculature and blood flow* [34,42]

Supports gut health*

Supports gut microbiota* [43–48]

Influences gut microbiota metabolism* [49]

Supports intestinal barrier function* [47,50]

Promotes healthy aging and longevity*

Supports healthy vascular function* [4,5]

Supports anti-senescence mechanisms* [51–53]

Supports the management of senescent cells* [54,55]

Supports cellular functions involved with pruning stressed cells* [56–64]

Supports autophagy* [52]

Supports stem cell proliferation* [53]

Supports cellular signaling* 

Influences PI3K/AKT signaling* [58]

Influences NF-κB signaling* [17,54,62,63,65]

Influences Nrf2 signaling* [54]

Complementary ingredients*

Quercetin for supporting cellular and tissue health* [66–71]

Luteolin for supporting endothelial function* [72]

Silymarin and silibinin (from milk thistle extracts) for supporting cellular and tissue health* [73–79]

Resveratrol in supporting the management of senescent cells* [80]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Piperlongumine (from Piper longum Root Extract)

Piperlongumine is an amide-alkaloid found in several species of pepper plants, most notably long pepper (Piper longum) from which it got its name. Long pepper is a close relative of one of the most widely used spices in the world, black pepper (Piper nigrum). The fruits and roots of long pepper are used as spices and in traditional healing systems including those found in India and Thailand. In Ayurveda, long pepper is considered a rasayana (rejuvenator), and black pepper and long pepper, along with ginger—collectively called Trikatu (“three pungent spices”)—is one of the most frequently used spice combinations. Long pepper has a taste similar to, but hotter and more complex than black pepper, and has often been used somewhat interchangeably as a spice: the word “pepper” is actually derived from the Sanskrit word for long pepper (pippali). Piperlongumine is one of the compounds that produce this stronger and more complex taste—long pepper fruits (and roots) contain piperlongumine, while black pepper does not. There has been a growing research interest in piperlongumine, with one of the areas of interest being as a potential senolytic compound.

TOP BENEFITS OF PIPERLONGUMINE

Supports healthy aging *

Supports cellular health *

Supports healthy brain aging *

QUALIA’S PIPERLONGUMINE SOURCING

Piperlongumine is produced from the roots of Piper longum (long pepper). The high-purity standardized extract we use contains not less than 95% piperlongumine.

Piperlongumine is non-GMO, gluten-free, and vegan.

PIPERLONGUMINE FORMULATING PRINCIPLES AND RATIONALE

Research suggests that piperlongumine has a broad range of effective servings, depending on its intended use and other ingredients it’s combined with. We chose a 50 mg recommended serving for Qualia Senolytic because the data suggests that this amount may play a complementary role with other ingredients used in the formula, since piperlongumine may have a unique senolytic mechanism [1] and has been reported to complement another senolytic compound [2]. Piperlongumine has been studied in a wide range of amounts in animal research, with even very low amounts of piperlongumine—equivalent to about 2 mg daily for humans—supporting aspects of healthy function in mice when added to the diet consistently [3]. Much higher servings, equivalent to several hundred mg daily have also been used in research [4].* 

PIPERLONGUMINE KEY MECHANISMS

Supports brain function*

Supports hippocampal and cognitive function in aged mice* [5]

Supports neuroprotective functions* [3,6,7]

Supports neural mitochondrial function* [6]

Supports cerebral endothelial progenitor cell function* [3]

Influences neural immune signaling* [8,9]

Influences astrocyte and microglia activation* [9]

Supports healthy biobehavioral responses to stress* [10,11]

Promotes healthy aging and longevity*

Supports the management of senescent cells* [1,2]

Supports cellular functions involved with pruning stressed cells* [2,12–21]

Supports autophagy* [6,14–17,21–23]

Supports stress resistance* [4]

Influences immune signaling* [24]

Supports natural killer (NK) cell binding to stressed cells* [25]

Supports cellular signaling*

Influences PI3K/AKT signaling* [13–15,17,20]

Influences mTOR signaling* [13–15,17]

Influences NF-κB signaling* [8,13,26]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Ginger Root Extract

Ginger is the common name for the whole or cut rhizome—the underground stem or vertical portion of the root—of the plant Zingiber officinale. Ginger has a long history of use as a food spice—it is one of the most widely used spices in the world. It also has a long history of use in Traditional Chinese Medicine (TCM), Ayurveda, and other healing systems. Ginger can be used alone, but is very commonly a part of poly-ingredient herbal combinations. In Ayurveda, as an example, the combination of ginger, black pepper, and long pepper, called Trikatu (“three pungent spices”), is frequently used together and also added to many other herb mixes. Modern science has discovered that ginger is a bioenhancer, positively influencing the bioavailability of some other compounds, which may partly explain why it’s often been combined with other herbs. Ginger contains many bioactive compounds, including several phenolic and terpene compounds. Gingerols, the compounds primarily responsible for the pungency of ginger root, are one of its main bioactive compounds. These pungent principles give ginger its characteristic flavor and spiciness; they also confer a number of health benefits. Ginger was used for a large number of health purposes historically. Modern science continues to investigate ginger in a wide range of areas, including brain, gastrointestinal, metabolic, musculoskeletal, and vision health.*

TOP BENEFITS OF GINGER ROOT EXTRACT

Supports healthy vision *

Supports cognitive function * 

Supports gastrointestinal health *

QUALIA’S GINGER ROOT EXTRACT SOURCING

Ginger Root Extract is standardized to contain not less than 5% Gingerols. Gingerols are among ginger’s main bioactive compounds that confer a number of health benefits.

Ginger Root Extract is gluten-free, non-GMO, vegan, Kosher, and Halal certified.

GINGER ROOT EXTRACT FORMULATING PRINCIPLES AND RATIONALE

Standardized ginger root extracts have been typically dosed from several hundred to 800 mg when used alone in human clinical studies. Given the responses to ginger in studies that have compared different doses, we consider ginger extracts to follow threshold dosing principles (see Qualia Dosing Principles), where much of the benefits occur in the lower-to-middle end of the dosage range. When ginger extracts are combined with other herbs, the amount used would normally be at the low end of the range. The serving of ginger extract used in our formulas will be dictated by what it’s being used to do and will follow amounts consistent with using an extract with a standardized amount of gingerols, ginger’s main bioactive compounds. When ginger extract is in a formula primarily for its role as a bioenhancer to enhance the bioavailability of other ingredients, the serving will be low (similar to piperine, it has not required a high amount of ginger for bioenhancement). When used for other purposes, the serving will be consistent with ranges for that purpose taking into account the other herb extracts used in combination with the ginger extract.*

GINGER ROOT EXTRACT KEY MECHANISMS

Supports vision*

Supports healthy retinal function* [1]

Supports healthy lens function* [2,3]

Supports protection from advanced glycation end-products (AGEs) formation in the eye lens* [1,2]

Supports antioxidant defenses* [4]

Supports retinal microvasculature* [5]

Supports brain function*

Supports cognitive function* [6,7]

Supports neuroprotective functions* [8–11]

Supports gastrointestinal function*

Supports healthy gut microbiome function* [12–15]

Supports digestive function (e.g., gastrointestinal motility, emptying, abdominal comfort)* [16–19]

Supports gut-brain axis* [20–23]

Supports mucosal- and gastro-protective functions* [24,25]

Supports antioxidant defenses*

Free radical scavenger* [10,26]

Counters ROS production and oxidative stress* [27–29]

Supports antioxidant defenses* [27–31]

Supports Nrf-2 signaling* [27,31,32]

Bioavailability enhancement*

Enhances bioavailability of β-carotene* [33,34]

Enhances bioavailability of minerals including calcium, iron, and zinc* [35]

Enhances lipid absorption by promoting bile acid secretion and lipase enzymes (so would be expected to support absorption of many fat-soluble nutrients)* [36]

Supports microvilli length and greater absorptive surface of the small intestine* [37]

Complementary ingredients*

Ginkgo biloba for healthy behavioral stress responses* [38–41]

Artichoke for digestive support* [42]

Turmeric for joint support* [43] and healthy metabolic function* [44]

Alpinia galanga for joint support* [45]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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