Gamma-oryzanol (γ-oryzanol) is a mixture of lipid molecules called steryl ferulates. Like many secondary metabolites in plants, and similar to tocopherols which also naturally occur in the oils of seeds, γ-oryzanol is considered to be an antioxidant. The best food source is rice bran and germ—γ-oryzanol gets its name from the botanical name for rice, Oryza sativa. γ-oryzanol has been sold in Japan since 1962, and most of the human studies on it have been done in Japan and published in non-English papers. These studies have focused primarily on supporting aspects of menopause, mood, nervous system, and heart health. Animal studies have suggested cognitive, mood, stress, immune and sleep support functions.*


Supports antioxidant defenses*
Supports brain function*


γ-Oryzanol is sourced from rice bran oil which goes through several extraction steps resulting in a finished product that contains not less than 97% γ-Oryzanol.

γ-Oryzanol is Non-GMO and Vegan.


One of our dosing principles is to determine whether there is a dosing range, in which many of the benefits occur and above which there appears to be diminishing returns (i.e., a threshold), and to provide a dose within this threshold range (see Qualia Dosing Principles ). We consider γ-oryzanol to be one of these threshold compounds. Very modest amounts of γ-oryzanol—10 to 50 mg a day—have been needed to produce a functional benefit in some of the human studies, so we will typically use a serving within this range. In parts of the world where rice bran oil is used or rice bran is consumed, it is a naturally occurring part of the diet; however, there would be a negligible amount found in a typical western diet. The modest serving of γ-oryzanol supplied can be thought of as augmenting the intake of an ingredient that’s not found in a meaningful amount in many people’s diets.*


Supports brain function*

Supports learning and memory (in animals)* [1–4]

Supports histaminergic neurotransmission* [5,6]

Supports adrenergic signaling* [7–9]

Supports serotonin signaling* [7–9]

Supports synaptic plasticity* [1]

Supports brain mitochondrial function and energy metabolism* [1,3,10,11]

Supports neuronal antioxidant defenses* [1,8,12–14]

Supports neuroprotective functions* [13,15–17]

Supports healthy behavioral and physiological responses to stress* [3,7,14,18–22]

Supports non-rapid eye movement (NREM) sleep* [5,6]

Supports antioxidant defenses*

Supports antioxidant enzymes* [1,14,17,23–25]  

Supports Nrf2 signaling* [24]

Supports phase II antioxidant enzymes (HO-1, NQO1)* [2,21,24]

Counters ROS production and oxidative stress* [14,17]

Supports healthy aging and longevity*

Supports healthy cardiovascular function* [23,26,27]

Supports healthy kidney function* [28–30]

Supports healthy metabolic function* [30–33]

Supports muscle strength* [34]

Supports immune performance* [35]

Supports mitochondrial function and biogenesis* [3,10,17]

Supports autophagy* [15,36]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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